Low Dose Naltrexone (LDN)
Doctor-prescribed low-dose naltrexone for metabolic support, appetite regulation, and patients seeking alternatives to GLP-1 treatment. Online consultation, no insurance required.
- Daily oral capsule, taken at bedtime
- May support appetite regulation and reduce food cravings
- Compounded at low doses (1.5mg–4.5mg) for off-label clinical use
- Prescribed by a licensed U.S. physician
- No insurance, no membership fees
- Free expedited shipping
Low-dose naltrexone (LDN) is the off-label use of naltrexone — an FDA-approved medication for opioid and alcohol use disorders — at doses dramatically lower than the standard prescription. At low doses (typically 1.5mg to 4.5mg daily), naltrexone briefly blocks opioid receptors, which prompts the body to compensate by upregulating its own endorphin production. This rebound effect appears to influence the immune system, modulate inflammation, and affect appetite signaling. LDN is increasingly used as an adjunct in metabolic health and weight management protocols, particularly for patients who can’t tolerate GLP-1 medications, who have inflammatory or autoimmune conditions affecting their metabolism, or who experience persistent food cravings that haven’t responded to other approaches. LDN is not FDA-approved for weight loss. A licensed provider determines whether LDN is appropriate based on your full medical history.
What’s included with my plan?
Your plan includes an online consultation with a licensed U.S. provider, your prescription if approved, your medication shipped from a state-licensed compounding pharmacy with free expedited delivery, and ongoing access to your provider for dose adjustments or questions throughout treatment. LDN protocols often involve gradual dose titration, so the provider relationship matters more here than for many other medications.
What treatment options are available with LDN?
Provn’s licensed providers may prescribe LDN for off-label clinical uses including metabolic support, appetite regulation, inflammatory and autoimmune conditions, and as an adjunct alongside other treatments. Your provider will discuss whether LDN is appropriate for your situation and what dose protocol fits your goals. LDN is typically used as part of a broader treatment approach rather than as a standalone weight-loss solution.
Can I cancel anytime?
Yes. Plans are month-to-month with no long-term commitment. You can cancel through your account dashboard or by contacting our support team at any time.
The statements on this page have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FSA & HSA eligible
Customized to your needs
Free shipping with all plans
Trusted brands
Start your weight loss journey
Care that knows your name
FSA & HSA eligible
Customized to your needs
Free shipping with all plans
Trusted brands
Start your weight loss journey
Care that knows your name
Designed for the patients GLP-1s don't reach.
A different mechanism for a different patient.
Discover other medication to hit your health goals
Provn connects patients with licensed providers who may prescribe medication through state-licensed pharmacies. Prescription medication is only available if prescribed after an online consultation with a licensed healthcare provider. Naltrexone is FDA-approved for the treatment of alcohol use disorder and opioid use disorder. Low-dose naltrexone (LDN) is the off-label use of naltrexone at lower doses than the FDA-approved indication. LDN is not approved by the FDA for weight loss, weight management, or any other condition. Off-label prescribing is a legal practice in which a licensed provider may prescribe a medication for a use other than its FDA-approved indication based on clinical judgment. Compounded medications are not FDA approved and are not reviewed by the FDA for safety or effectiveness. LDN should not be taken with opioid medications. Tell your provider about all medications, supplements, and medical conditions before starting treatment. Statements on this page have not been evaluated by the Food and Drug Administration. Individual results may vary. Plans are offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown.
FAQs
What is low-dose naltrexone (LDN)?
Low-dose naltrexone is the off-label use of naltrexone — an FDA-approved medication for alcohol and opioid use disorder — at much lower doses than the FDA-approved indication. At standard doses (50mg), naltrexone blocks opioid receptors. At low doses (1.5mg to 4.5mg), naltrexone briefly blocks opioid receptors and triggers the body to upregulate its own endorphin production. This rebound effect appears to modulate the immune system and affect inflammatory and metabolic pathways.
Is LDN approved by the FDA for weight loss?
No. LDN is not FDA-approved for weight loss, weight management, or any condition other than the standard-dose use for alcohol and opioid use disorders. LDN is prescribed off-label, which is a legal practice in which a licensed provider may prescribe a medication for a use other than its FDA-approved indication based on clinical judgment. Off-label prescribing is common across many medications and is not the same as unapproved or experimental treatment.
How does LDN differ from GLP-1 medications?
GLP-1 medications like semaglutide and tirzepatide work directly on appetite hormones, slowing digestion and reducing hunger signals. LDN works on a different system entirely — modulating the body’s endorphin response and inflammatory pathways. The two approaches address different aspects of metabolic health, and some patients respond better to one than the other. Some clinical protocols combine the two, though this is determined case by case by a licensed provider.
Who is a good candidate for LDN?
LDN may be considered for patients dealing with metabolic inflammation, autoimmune conditions affecting weight, persistent food cravings that haven’t responded to other approaches, or as an alternative for patients who can’t tolerate GLP-1 medications. A licensed provider determines eligibility based on your full medical history, current medications, and treatment goals. LDN is not appropriate for patients currently using opioid medications or with certain liver conditions.
What are the most common side effects?
LDN is generally well-tolerated at low doses. The most commonly reported side effects are vivid dreams, mild sleep disturbances during the first few weeks of treatment, and occasional headaches. Most side effects diminish as the body adjusts. Serious side effects are rare. LDN should not be combined with opioid medications, and patients with significant liver disease should be evaluated carefully before starting treatment.
How is LDN dosed?
LDN is typically taken as an oral capsule once daily at bedtime. Most providers start patients at a low dose (often 1.5mg) and titrate up gradually based on response, sometimes reaching 4.5mg over several weeks. Dose protocols vary based on the condition being treated and individual response. Your provider will design a specific protocol for your situation.
Do I need a prescription?
Yes. Naltrexone — at any dose, including low doses — is a prescription-only medication. Provn connects you with a licensed U.S. physician who reviews your medical history and determines if LDN is appropriate. The consultation is online and takes only a few minutes.
Can I cancel anytime?
Yes. Plans are month-to-month with no long-term commitment. You can cancel through your account dashboard or by contacting our support team at any time.