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Low Dose Naltrexone (LDN)

Doctor-prescribed low-dose naltrexone, compounded at 1.5mg to 4.5mg and taken as a daily capsule. Online consultation with a licensed U.S. provider, no insurance required.

No membership · No hidden fees
FSA/HSA eligible

LDN​ plans

Monthly

$95/month

3-month

$86/month

Most popular

6-month

$81/month

12-month

$76/month
Get started
  • Cancel Anytime
  • Free Shipping
  • Licensed Provider

Naltrexone is FDA-approved at 50 mg for opioid and alcohol use disorder. Compounded low-dose naltrexone is a separate preparation, prescribed off-label at 1.5–4.5 mg, and is not FDA-approved for weight loss. Not for use with opioid medications.

  • Daily oral capsule, taken at bedtime
  • Brief opioid receptor blockade that prompts the body's own endorphin production
  • Compounded at low doses (1.5mg–4.5mg) for off-label clinical use
  • Prescribed by a licensed U.S. physician
  • No insurance, no membership fees
  • Free expedited shipping

Low-dose naltrexone (LDN) is the off-label use of naltrexone, an FDA-approved medication for opioid and alcohol use disorders, at doses far lower than the standard prescription. At low doses (typically 1.5mg to 4.5mg daily), naltrexone briefly blocks opioid receptors, which prompts the body to compensate by upregulating its own endorphin production. This rebound effect has been studied for its influence on endorphin signaling and inflammatory pathways. LDN is not FDA-approved for weight loss. A licensed provider determines whether LDN is appropriate based on your full medical history.

Your plan includes an online consultation with a licensed U.S. provider, your prescription if approved, your medication shipped from a state-licensed compounding pharmacy with free expedited delivery, and ongoing access to your provider for dose adjustments or questions throughout treatment. LDN protocols often involve gradual dose titration, so the provider relationship matters more here than for many other medications.

Provn’s licensed providers may prescribe LDN off-label based on clinical judgment. Your provider reviews your medical history and current medications, decides whether LDN is appropriate, and sets the dose protocol. LDN is typically used as part of a broader treatment plan directed by your provider.

Yes. Plans are month-to-month with no long-term commitment. You can cancel through your account dashboard or by contacting our support team at any time.

The statements on this page have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

No membership · No hidden fees
FSA/HSA eligible

Low Dose Naltrexone (LDN)

Doctor-prescribed low-dose naltrexone, compounded at 1.5mg to 4.5mg and taken as a daily capsule. Online consultation with a licensed U.S. provider, no insurance required.

LDN​ plans

Monthly

$95/month

3-month

$86/month

Most popular

6-month

$81/month

12-month

$76/month
Get started
  • Cancel Anytime
  • Free Shipping
  • Licensed Provider

Naltrexone is FDA-approved at 50 mg for opioid and alcohol use disorder. Compounded low-dose naltrexone is a separate preparation, prescribed off-label at 1.5–4.5 mg, and is not FDA-approved for weight loss. Not for use with opioid medications.

  • Daily oral capsule, taken at bedtime
  • Brief opioid receptor blockade that prompts the body's own endorphin production
  • Compounded at low doses (1.5mg–4.5mg) for off-label clinical use
  • Prescribed by a licensed U.S. physician
  • No insurance, no membership fees
  • Free expedited shipping

Low-dose naltrexone (LDN) is the off-label use of naltrexone, an FDA-approved medication for opioid and alcohol use disorders, at doses far lower than the standard prescription. At low doses (typically 1.5mg to 4.5mg daily), naltrexone briefly blocks opioid receptors, which prompts the body to compensate by upregulating its own endorphin production. This rebound effect has been studied for its influence on endorphin signaling and inflammatory pathways. LDN is not FDA-approved for weight loss. A licensed provider determines whether LDN is appropriate based on your full medical history.

Your plan includes an online consultation with a licensed U.S. provider, your prescription if approved, your medication shipped from a state-licensed compounding pharmacy with free expedited delivery, and ongoing access to your provider for dose adjustments or questions throughout treatment. LDN protocols often involve gradual dose titration, so the provider relationship matters more here than for many other medications.

Provn’s licensed providers may prescribe LDN off-label based on clinical judgment. Your provider reviews your medical history and current medications, decides whether LDN is appropriate, and sets the dose protocol. LDN is typically used as part of a broader treatment plan directed by your provider.

Yes. Plans are month-to-month with no long-term commitment. You can cancel through your account dashboard or by contacting our support team at any time.

The statements on this page have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FSA & HSA eligible Customized to your needs Free shipping with all plans Trusted brands Prescribed online by licensed U.S. providers Care that knows your name
FSA & HSA eligible Customized to your needs Free shipping with all plans Trusted brands Prescribed online by licensed U.S. providers Care that knows your name

Designed for the patients GLP-1s don't reach.

A different mechanism for a different patient.

  • A non-GLP-1 approach to metabolic health. Low-dose naltrexone works through the body's endorphin and immune systems.
  • LDN has a growing body of clinical research across autoimmune conditions, chronic inflammation, and metabolic regulation.
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Provn connects patients with licensed providers who may prescribe medication through state-licensed pharmacies. Prescription medication is only available if prescribed after an online consultation with a licensed healthcare provider. Naltrexone is FDA-approved for the treatment of alcohol use disorder and opioid use disorder. Low-dose naltrexone (LDN) is the off-label use of naltrexone at lower doses than the FDA-approved indication. LDN is not approved by the FDA for weight loss, weight management, or any other condition. Off-label prescribing is a legal practice in which a licensed provider may prescribe a medication for a use other than its FDA-approved indication based on clinical judgment. Compounded medications are not FDA approved and are not reviewed by the FDA for safety or effectiveness. LDN should not be taken with opioid medications. Tell your provider about all medications, supplements, and medical conditions before starting treatment. Statements on this page have not been evaluated by the Food and Drug Administration. Individual results may vary. Plans are offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown.

Start personalized Low Dose Naltrexone care from home

  • Dedicated 1-on-1 support from licensed U.S.-based healthcare professionals
  • Fast delivery and 24/7 support whenever you need assistance
  • Quick, dependable shipping with around-the-clock customer support
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FAQs

Need More Answers?
What is low-dose naltrexone (LDN)?

Low-dose naltrexone (LDN) is the off-label use of naltrexone, an FDA-approved medication for opioid and alcohol use disorders, at doses far lower than the standard prescription. At low doses (typically 1.5mg to 4.5mg daily), naltrexone briefly blocks opioid receptors, which prompts the body to compensate by upregulating its own endorphin production. This rebound effect has been studied for its influence on endorphin signaling and inflammatory pathways. LDN is not FDA-approved for weight loss. A licensed provider determines whether LDN is appropriate based on your full medical history.

No. LDN is not FDA-approved for weight loss, weight management, or any condition other than the standard-dose use for alcohol and opioid use disorders. LDN is prescribed off-label, which is a legal practice in which a licensed provider may prescribe a medication for a use other than its FDA-approved indication based on clinical judgment. Off-label prescribing is common across many medications and is not the same as unapproved or experimental treatment.

GLP-1 medications act on incretin hormone pathways and slow gastric emptying. LDN acts on a different system, briefly blocking opioid receptors and prompting the body to upregulate its own endorphin production, which has been studied for its effect on inflammatory pathways. Whether either is appropriate, or whether they are used together, is determined case by case by a licensed provider.

A licensed provider determines eligibility based on your full medical history, current medications, and the reason you are seeking treatment. LDN is not appropriate for patients currently using opioid medications or with certain liver conditions.

LDN is generally well-tolerated at low doses. The most commonly reported side effects are vivid dreams, mild sleep disturbances during the first few weeks of treatment, and occasional headaches. Most side effects diminish as the body adjusts. Serious side effects are rare. LDN should not be combined with opioid medications, and patients with significant liver disease should be evaluated carefully before starting treatment.

LDN is typically taken as an oral capsule once daily at bedtime. Most providers start patients at a low dose (often 1.5mg) and titrate up gradually based on response, sometimes reaching 4.5mg over several weeks. Dose protocols vary based on the condition being treated and individual response. Your provider will design a specific protocol for your situation.

Yes. Naltrexone — at any dose, including low doses — is a prescription-only medication. Provn connects you with a licensed U.S. physician who reviews your medical history and determines if LDN is appropriate. The consultation is online and takes only a few minutes.

Yes. Plans are month-to-month with no long-term commitment. You can cancel through your account dashboard or by contacting our support team at any time.

Naltrexone is FDA-approved for the treatment of alcohol use disorder and opioid use disorder at standard doses. Low-dose naltrexone (LDN) is the off-label use of naltrexone at lower doses than the FDA-approved indication. LDN is not FDA-approved for weight loss, weight management, autoimmune conditions, chronic pain, or any other condition outside its FDA-approved indications. Off-label prescribing is a legal practice in which a licensed provider may prescribe an FDA-approved medication for a use other than its FDA-approved indication based on clinical judgment. Off-label prescribing is common across many medications and is not the same as unapproved or experimental treatment. Compounded LDN is prepared by state-licensed compounding pharmacies based on a prescription from a licensed healthcare provider. Compounded medications are not reviewed by the FDA for safety or effectiveness. LDN should not be taken with opioid medications. Tell your provider about all medications, supplements, and medical conditions before starting treatment. Individual results may vary. Plans are offered as a subscription service which you can cancel at any time.