Weight Loss Medication Online,Prescribed by Licensed Providers

Provn connects you with licensed U.S. providers who can prescribe compounded semaglutide and compounded tirzepatide, two once-weekly GLP-1 injections, online.

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Compounded Semaglutide
Compounded Tirzepatide
Online review, usually same-day
By a licensed provider in your state
Weekly injection or daily capsule
Chosen by your provider
Usually same-day
Online review by a licensed provider in your state
GLP-1 plans from $143/month
On a 12-month plan. FSA and HSA eligible
Free, discreet shipping
In plain packaging

Providers may also prescribe low dose naltrexone (LDN), a daily capsule, off-label. You take a short online health quiz, a provider in your state reviews it in a same-day consultation, and if treatment is right for you, your medication ships free in plain packaging. No insurance needed.

Semaglutide

starting at 

$143

/month

Tirzepatide

starting at 

$229

/month

Naltrexone

starting at 

$76

/month

Compounded Semaglutide vs. Tirzepatide vs. Low Dose Naltrexone

Semaglutide and tirzepatide are GLP-1 medications for weight management. LDN is a different, non-GLP-1 option that some providers prescribe off-label. All three work in different ways.

How often you take itOne week shown. Your provider sets your exact schedule.
MonTueWedThuFriSatSun
SemaglutideWeekly injection
TirzepatideWeekly injection
Low dose naltrexoneDaily capsule at bedtime
InjectionCapsule
Compounded semaglutide Compounded tirzepatide Low dose naltrexone (LDN)
TypeGLP-1 receptor agonistDual-action GIP and GLP-1 receptor agonistNon-GLP-1. Low-dose opioid receptor blocker
How you take itWeekly injectionWeekly injectionDaily capsule at bedtime
How it worksHelps you feel full sooner, slows how quickly your stomach empties, and helps regulate blood sugarActs on two hormone pathways that affect appetite, fullness, and blood sugarBriefly blocks opioid receptors, which is thought to prompt the body to increase its own endorphin production
May suit you ifYou want a once-weekly GLP-1You want a dual-action GLP-1 optionYou'd prefer a daily capsule to a weekly injection
Starting price$143/mo12-month plan. $179 monthly plan$229/mo3-month plan. $297 monthly plan$76/mo12-month plan. $95 monthly plan

Your provider decides which treatment and dose fit your health history.

Compounded semaglutide and tirzepatide aren’t FDA-approved. LDN is compounded and prescribed off-label: naltrexone on its own is FDA-approved at 50 mg for opioid and alcohol use disorder, not for weight loss. For weight management, naltrexone is FDA-approved only in combination with bupropion.

How Weight Loss Medication Works

Overweight and obesity are common. Prescription weight loss drugs can help some people lose weight when used alongside healthy eating and physical activity, but they don’t replace those healthy habits.

U.S. adults have obesity
0 in 10
May qualify for weight loss medication
BMI 0 +
With a weight-related health condition, such as high blood pressure or type 2 diabetes
BMI 0 +

Source: NIDDK

Who may qualify for weight loss medication

You may be a candidate if you’re an adult with a body mass index (BMI) of 30 or higher, or 27 or higher with weight-related health conditions such as high blood pressure or type 2 diabetes (NIDDK). Your provider also looks at your weight history, health history, other medical conditions, current medications, and goals.

Not appropriate if

GLP-1s: you have a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2 (MEN 2)

GLP-1s: you’re pregnant or planning a pregnancy

LDN: you take opioid medications. People with significant liver disease need a careful evaluation first

How GLP-1 medications work

Semaglutide mimics GLP-1, a hormone your body makes naturally. It signals fullness to your brain, helps regulate appetite, slows how quickly your stomach empties, and helps regulate blood sugar. Tirzepatide acts on two hormone receptors, GIP and GLP-1, which is why it’s called a dual-action medication. Both GLP-1s work gradually, and your provider increases your dose over time based on how your body responds.

Semaglutide GLP-1
Tirzepatide GIP + GLP-1
01
Mimics GLP-1

A hormone your body makes naturally

02
Signals fullness and helps regulate appetite

The fullness signal goes to your brain

03
Slows stomach emptying

How quickly your stomach empties

04
Helps regulate blood sugar

Tirzepatide also acts on GIP

How LDN is different

At low doses, typically 1.5 mg to 4.5 mg a day, naltrexone briefly blocks opioid receptors, which is thought to prompt the body to increase its own endorphin production. It works through a different system than GLP-1 medications and is taken as a capsule at bedtime. LDN is not FDA-approved for weight loss. A provider may prescribe it off-label, which is a legal practice, based on clinical judgment.

1.5 to 4.5 mg
Daily, at bedtime
Non-GLP-1
Off-label

What weight loss medication can and can't do

! Takes time

It isn't a quick fix.

It works gradually, and doses usually start low and increase over time.

✓ Works best with

It works alongside lifestyle changes.

Medication doesn’t replace healthy eating or physical activity.

! Good to know

Treatment length varies.

Some patients continue at a maintenance dose. Others taper off with their provider’s guidance.

! Results vary

The 12-week check.

If you don’t lose at least 5% of your starting body weight after 12 weeks on the full dose, your provider will likely suggest stopping or trying a different approach (NIDDK).

Week 0
Week 12
↺ Weight regain

Weight regain is common.

You’ll probably regain some weight after you stop, though healthy eating and more physical activity may limit that (NIDDK).

No single best option

Some patients respond better to one GLP-1 than the other.

Choosing between medications for weight loss

There’s no single best weight loss medication. Some patients respond better to one GLP-1 than the other. Your provider will consider:

01

Your weight history and BMI

02

Your health history, including thyroid, pancreas, and gallbladder conditions

03

Every medication you take, including any opioid medications

04

Whether you’ve taken a GLP-1 before, and how you tolerated it

05

Whether you’d prefer a weekly injectable medication or a daily capsule

Licensed providers in your state Online review, usually same-day Free, discreet shipping No insurance needed FSA and HSA eligible LegitScript certified
Licensed providers in your state Online review, usually same-day Free, discreet shipping No insurance needed FSA and HSA eligible LegitScript certified

How Online Weight Loss Treatment Works With Provn

Four steps, from your first answer to your door.

01

Take the health quiz.

Answer questions about your weight history, health history, current medications, and goals. It takes a few minutes.

02

A licensed provider reviews it.

A provider in your state reviews your answers, usually in a same-day consultation, and checks whether you meet the criteria for treatment and whether anything would make a medication unsafe for you.

03

Get your prescription and dosing plan, if it's right for you.

Your provider chooses the medication and a starting dose, sets a personalized treatment plan, and explains how your dose may change over time. A state-licensed compounding pharmacy prepares it.

04

It ships free and discreetly.

Most patients receive their medication within 3 to 5 business days of being prescribed, in a plain, temperature-controlled box.

Free expedited shipping

Pricing and plans

Compounded semaglutide
12-month plan, up to $179 monthly

From $143/mo

Compounded tirzepatide
3-month plan, or $297 monthly

From $229/mo

Low dose naltrexone
12-month plan, up to $95 monthly

From $76/mo
No insurance needed
FSA and HSA eligible
Consultation included
Ongoing provider access

Your plan includes your online consultation, your prescription if approved, free expedited shipping, and ongoing access to your provider. Cancel from your account dashboard or by contacting support, before your next renewal date. Unused GLP-1 medication is yours to keep. Provn serves patients in 46 states. Availability can vary by state.

After that, you keep access to your provider for questions and dose adjustments throughout treatment.

See the full process →

Is Weight Loss Medication Safe for You?

Weight loss medication isn’t right for everyone. That’s why every Provn prescription starts with a provider reviewing your health history.

Common GLP-1 side effects

Nausea
Vomiting
Diarrhea
Constipation
Stomach pain

Nausea, vomiting, diarrhea, constipation, and stomach pain are among the most common side effects of semaglutide and tirzepatide. They’re usually most noticeable when you start or increase your dose, and for most patients they ease as the body adjusts. Less common but more serious side effects include pancreatitis, gallbladder problems, kidney problems, low blood sugar (especially with diabetes medications), and changes in vision. Tell your healthcare provider about any unusual symptoms during treatment.

Both medications carry an FDA boxed warning about thyroid C-cell tumors, which were seen in rodent studies.

Get medical attention right away for:

Severe abdominal pain

Persistent vomiting

Signs of an allergic reaction

A lump or swelling in your neck, hoarseness, or trouble swallowing

Thoughts of suicide or self-harm, or new or worsening depression

LDN side effects

The most commonly reported side effects of LDN are vivid dreams, mild sleep disturbances in the first few weeks, and occasional headaches. They usually ease as the body adjusts. Never combine LDN with opioid medications, and tell your provider about all other medications you take.

Compounded and FDA-approved GLP-1 medications

✓ FDA-approved

Brand-name semaglutide and tirzepatide medications

Are FDA-approved.

! Not FDA-approved

Compounded medications, including compounded semaglutide and tirzepatide

This is the type Provn’s partner pharmacies prepare. They’re made by a state-licensed compounding pharmacy for an individual patient. A provider can prescribe them when a compounded medication is clinically appropriate for an individual patient, but they aren’t FDA-approved, and the FDA doesn’t review them for safety, effectiveness, or quality. Provn’s are prepared from the base form of each active ingredient, sourced from FDA-registered facilities.

! Safety tip

Measure your dose carefully.

The FDA has received reports of dosing errors with compounded semaglutide when patients measured and gave themselves the wrong dose (FDA). Follow your provider’s instructions exactly, and ask if you’re unsure how much to take.

How to Buy Weight Loss Medication Online Safely

Semaglutide, tirzepatide, and naltrexone are prescription-only medications. The FDA warns that counterfeit GLP-1 drugs can contain the wrong ingredients, and it urges people to buy only from state-licensed pharmacies (FDA). Before you order weight loss medication online, check that:

  • A licensed provider reviews your health history before anything is prescribed
  • The pharmacy is licensed by a state board of pharmacy
  • You can see the full price before you commit
  • Your health information is protected under HIPAA

The FDA’s guide to buying medicine safely online covers the pharmacy side in more detail.

LegitScript certified

Provn is LegitScript certified, which you can verify on LegitScript’s site.

Other prescription weight loss medications

Orlistat
Phentermine-topiramate
Naltrexone-bupropion (Contrave)
Liraglutide (Saxenda)
Semaglutide (Wegovy)
Tirzepatide (Zepbound)

Several medications are approved by the FDA for long-term weight management, including the ones above (NIDDK). Provn’s providers prescribe compounded semaglutide and tirzepatide, which aren’t FDA-approved, and low dose naltrexone off-label. If you’re interested in another medication, talk with your doctor.

Weight Loss Medication Online: Frequently Asked Questions

Need More Answers?
Can I get weight loss medication online?

Yes, with a medical review. A licensed provider reviews your health information online and prescribes treatment only if it’s appropriate.

Neither is best for everyone. Semaglutide acts on one hormone receptor (GLP-1), and tirzepatide acts on two (GIP and GLP-1). Some patients respond better to one than the other, so your provider makes the choice based on your history, goals, and how your body responds.

No. Compounded semaglutide is not Wegovy or Ozempic. It’s prepared by a compounding pharmacy, it isn’t FDA-approved, and the FDA doesn’t review compounded drugs for safety, effectiveness, or quality.

No. Compounded tirzepatide is not Zepbound or Mounjaro. It’s prepared by a compounding pharmacy, it isn’t FDA-approved, and the FDA doesn’t review compounded drugs for safety, effectiveness, or quality.

Possibly. Your provider will review your history and set an appropriate starting dose.

No. It works through a different system and is taken by mouth once a day. LDN isn’t FDA-approved for weight loss and is prescribed off-label.

Compounded semaglutide starts at $143/month, compounded tirzepatide at $229/month, and LDN at $76/month. Your price depends on your plan length.

No. Provn’s weight loss treatments don’t require insurance. Your out-of-pocket cost is your plan price, and treatments are FSA and HSA eligible.

Consultations are usually same-day. After you’re prescribed, most patients receive their medication within 3 to 5 business days.

You’ll probably regain some weight after you stop. Talk with your provider first. Some patients continue at a maintenance dose, and others taper off with their provider’s guidance.

Related guides

How GLP-1 medications work for weight loss

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Semaglutide vs. tirzepatide: which is right for you

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GLP-1 side effects: what's common, what's rare, and what's serious

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GLP-1 cost without insurance

GLP-1 cost without insurance

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How to Get Low Dose Naltrexone (LDN) Online: Five Checks

How to get low dose naltrexone online

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Woman using a laptop on her sofa at home

How Provn works

Read guide →

Find the weight loss treatment that fits you.

Take the health quiz, and a licensed provider in your state will review it, usually the same day.

Take the quiz